Resumo Atualmente a epidemia do HIV/Aids continua sendo um problema de saúde pública de ampla relevância, e quando não há uma boa aderência do paciente ao tratamento o mesmo torna-se suscetível a outras infecções como a toxoplasmose. Objetivou-se avaliar a força de preensão manual e a qualidade de vida em pacientes infectados pelo HIV com diagnóstico de neurotoxoplasmose. Foi realizado um estudotransversal com 40 pacientes infectados pelo HIV, com e sem diagnóstico de neuroxoplasmose. Foram coletadas informações sociodemográficas, perfil clínico e foram avaliadas a força de preensão manual e a qualidade de vida. Quase todos os pacientes de ambos os grupos utilizavam a terapia antirretroviral.Na avaliação de força de preensão manual não notou-se diferença estatística para a força manual direita e esquerda entre os grupos com e sem neurotoxoplasmose (p>0.05). Contudo, a classificação de inadequado para a força manual no grupo com neurotoxoplasmose foi significativamente maior. Nos domínios da qualidade de vida, observou-se que a preocupação financeira apresentou menores escoresno grupo com neurotoxoplasmose (p=0.0379). Observou-se que a neurotoxoplasmose não demonstrou associação com as variáveis epidemiológicas, clínicas, da força manual e da qualidade de vida. Contudo os pacientes com neurotoxoplasmose apresentaram uma tendência para menor força muscular.

Abstract HIV / AIDS epidemic continues to be a major public health problem, and when there is poor adherence to treatment, patients become susceptible to other infections such as toxoplasmosis. The aim of this study was to evaluate the handgrip strength and quality of life of HIV infected patients diagnosed with neurotoxoplasmosis. A cross-sectional study was conducted with 40 HIV-infected patients, with and without diagnosis of neuroxoplasmosis.Sociodemographic and clinical profile information was collected, and handgrip strength and quality of life were evaluated. Almost all patients of both groups used antiretroviral therapy. In the handgrip strength evaluation, no statistical difference was observed for the right and left hand between groups with and without neurotoxoplasmosis (p> 0.05). However, the classifica-1 Federal University of Pará. Gradution of inadequate handgrip strength in the neurotoxoplasmosis group was significantly higher.ate Program in Tropical Diseases. In the quality of life domain, it was observed that financial concern had lower scores in the Belém, PA. Brazil. group with neurotoxoplasmosis (p = 0.0379). It was observed that neurotoxoplasmosis showedno association with epidemiological, clinical, handgrip strength and quality of life variables.2 State University of Pará. Center However, patients with neurotoxoplasmosis showed a trend towards lower muscle strength.

The most common hemoglobinopathies, viz, hemoglobins S and C, and α-and β-thalassemias, were investigated through the molecular screening of 116 subjects from the community of Saracura, comprising fugitive African slaves from farms of the municipality of Santarém, in the west of Pará State, Brazilian Amazon. The observed frequency of the HBB*S gene (0.9%) was significantly lower than that encountered in other Afro-derived communities in the region. Concomitantly, the absence of the HBB*C allele has been reported for most of the Afro-Amazonian communities thus far studied. As remnant populations of quilombos are generally small, the heterogeneous distribution of HBB*S and HBB*C alleles among them is probably due to genetic drift and/or founder effect. The observed frequency of 3.7 kb deletion in Saracura (8.5%) was consistent with the African origin of the population, with a certain degree of local differentiation and admixture with individuals of Caucasian ancestry, placed in evidence by the occurrence of - -(MED) deletion (1.2%), a common mutation in Mediterranean regions. As regards f-thalassemia, among the seven different mutations found in Saracura, three βºand two β+ mutations were of Mediterranean origin, and two β+ of African. Thus, only 28% of the local β-thalassemia mutations found in Saracura were of African origin.